Raghavendra G Mirmira Selected Research

hypusine

4/2022	Role of Polyamines and Hypusine in β Cells and Diabetes Pathogenesis.
12/2019	Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis.
1/2019	Recessive Rare Variants in Deoxyhypusine Synthase, an Enzyme Involved in the Synthesis of Hypusine, Are Associated with a Neurodevelopmental Disorder.
3/2014	Protective effects of polyamine depletion in mouse models of type 1 diabetes: implications for therapy.
7/2010	Hypusine: a new target for therapeutic intervention in diabetic inflammation.
6/2010	The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice.

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Raghavendra G Mirmira Research Topics

Disease

42	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2022 - 05/2008
18	Inflammation (Inflammations) 04/2022 - 06/2010
15	Type 2 Diabetes Mellitus (MODY) 02/2021 - 02/2008
10	Insulin Resistance 12/2019 - 02/2008
8	Obesity 02/2021 - 04/2011
7	Hyperglycemia 01/2020 - 10/2008
5	Glucose Intolerance 11/2021 - 06/2010
5	Neoplasms (Cancer) 01/2021 - 02/2018
3	Insulinoma 01/2009 - 04/2005
2	Non-alcoholic Fatty Liver Disease 02/2022 - 11/2017
2	Nausea 01/2022 - 01/2021
2	Metabolic Diseases (Metabolic Disease) 11/2021 - 12/2017
2	Diabetes Mellitus 04/2011 - 02/2010
2	Mason-Type Diabetes 11/2009 - 09/2007
1	Anorexia 01/2022
1	Breast Neoplasms (Breast Cancer) 01/2021
1	Pancreatic Diseases (Pancreatic Disease) 01/2021
1	Virus Diseases (Viral Diseases) 10/2020
1	Carcinogenesis 12/2019
1	Necrosis 11/2019
1	Neurodevelopmental Disorders 01/2019
1	Vitamin D Deficiency 01/2019
1	Ketosis 01/2018
1	HIV Seropositivity 01/2018
1	Ganglion Cysts (Ganglion) 01/2018
1	HIV Infections (HIV Infection) 01/2018
1	Weight Gain 10/2016
1	Sepsis (Septicemia) 01/2015

Drug/Important Bio-Agent (IBA)

30	Insulin (Novolin)FDA Link 04/2022 - 04/2005
14	CytokinesIBA 02/2022 - 06/2010
10	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 05/2005
9	Biomarkers (Surrogate Marker)IBA 02/2021 - 02/2016
8	EnzymesIBA 11/2021 - 12/2010
7	DNA (Deoxyribonucleic Acid)IBA 02/2021 - 11/2015
6	hypusineIBA 04/2022 - 06/2010
6	Proteins (Proteins, Gene)FDA Link 10/2020 - 04/2005
6	ProinsulinIBA 11/2019 - 06/2014
5	C-PeptideIBA 01/2021 - 02/2008
5	deoxyhypusine synthaseIBA 12/2019 - 12/2010
4	Arachidonate 12-Lipoxygenase (12 Lipoxygenase)IBA 01/2021 - 10/2014
3	PolyaminesIBA 04/2022 - 03/2014
3	Pharmaceutical PreparationsIBA 02/2022 - 07/2010
3	Arachidonate 15-Lipoxygenase (Arachidonate 15 Lipoxygenase)IBA 01/2022 - 01/2013
3	Cell-Free Nucleic AcidsIBA 02/2021 - 01/2019
3	AutoantibodiesIBA 01/2021 - 09/2016
3	Streptozocin (Streptozotocin)FDA Link 03/2014 - 06/2010
2	Pioglitazone (Actos)FDA Link 02/2022 - 10/2016
2	LipidsIBA 02/2022 - 01/2015
2	EpitopesIBA 10/2021 - 10/2021
2	GlutaminaseIBA 01/2021 - 10/2020
2	RNA (Ribonucleic Acid)IBA 12/2020 - 11/2019
2	preproinsulinIBA 12/2016 - 11/2015
2	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 10/2016 - 10/2008
2	Nonesterified Fatty Acids (NEFA)IBA 07/2015 - 10/2014
2	Messenger RNA (mRNA)IBA 06/2010 - 10/2008
2	Transcription Factors (Transcription Factor)IBA 11/2009 - 10/2008
2	Small Interfering RNA (siRNA)IBA 01/2009 - 04/2005
1	Doxycycline (Periostat)FDA LinkGeneric 02/2022
1	SolutionsIBA 01/2022
1	Glucagon (Glukagon)FDA Link 11/2021
1	Ligases (Synthetase)IBA 01/2021
1	CreatineIBA 01/2021
1	EicosanoidsIBA 01/2021
1	Acyl Coenzyme A (Acyl CoA)IBA 01/2021
1	glycine amidinotransferase (arginine-glycine amidinotransferase)IBA 01/2021
1	Imatinib Mesylate (Gleevec)FDA Link 01/2021
1	IsoenzymesIBA 10/2020
1	Coloring Agents (Dyes)IBA 10/2020
1	TYK2 Kinase (Tyrosine Kinase 2)IBA 10/2020
1	Apoptosis Regulatory ProteinsIBA 01/2020
1	Collagen Type I (Type I Collagen)IBA 01/2020
1	SpermidineIBA 12/2019
1	Cyclin D2IBA 12/2019
1	Vitamin D FDA LinkGeneric 01/2019
1	Protein Isoforms (Isoforms)IBA 01/2019
1	Aldehyde Dehydrogenase 1 FamilyIBA 05/2018
1	Hormones (Hormone)IBA 02/2018
1	ursodoxicoltaurineIBA 01/2018
1	Janus KinasesIBA 01/2018
1	Retinaldehyde (Retinal)IBA 01/2018
1	Janus Kinase InhibitorsIBA 01/2018
1	Mechanistic Target of Rapamycin Complex 1IBA 12/2017
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2017
1	InterferonsIBA 01/2017
1	Biological ProductsIBA 01/2017
1	CytosineIBA 12/2016
1	ThiazolidinedionesIBA 10/2016
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 10/2016
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 02/2016
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 07/2015
1	Volatile Fatty AcidsIBA 07/2015
1	Myeloid Differentiation Factor 88IBA 01/2015

Therapy/Procedure

12	Therapeutics 01/2022 - 02/2010
3	Transplantation 10/2018 - 11/2013
1	Chronotherapy 01/2022
1	Islets of Langerhans Transplantation 02/2021
1	Glycemic Control 01/2020
1	Subcutaneous Injections 01/2020
1	Art Therapy 01/2018
1	Lasers (Laser) 01/2017